hrp0084p2-372 | Fat | ESPE2015

The Effect of ABCA1 Gene C69T Single Nucleotide Polymorphism on Dyslipidemia and Insulin Resistance in Obese Children

Ozgen Ilker Tolga , Erenberk Ufuk , Gok Ozlem , Kilic Ulkan , Bayraktar-Tanyeri Bilge , Torun Emel , Aksu Mehmet Sirin , Cesur Yasar

Background: ATP-binding cassette transporter A1 (ABCA1) mediates the transport of cholesterol and phospholipids from cells to lipid-poor apolipoproteins. It has been demonstrated that the ABCA1 gene C69T single nucleotide polymorphism (SNP; TT genotype) is associated with lower HDL cholesterol and higher triglycerides (TG) levels. The relation of this polymorphism with type 2 diabetes mellitus has also been shown.Objective and hypotheses: As dys...